Making e-learning accessible to learners with disabilities has been a major challenge for educational institutions. Dakota State University (DSU) has been making consolidated efforts to meet the challenge. With years of experience and field expertise in disability services, an interdisciplinary team has been formed to serve as a spearhead in exploring technologies, developing strategies, and coordinating efforts to make learning more accessible to both onsite and online learners. The session will introduce the technologies utilized and share the experiences DSU has acquired through years of exploration and practice.